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Preclinical findings already demonstrate that the same intervention, such as TrxR inhibition, can have opposite effects in T cells versus macrophages

Chaneton B, Hillmann P, Zheng L, Martin ACL, Maddocks ODK, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH et al (2012) Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Testing Elevated SAH and Undermethylation Symptoms suggest where to look, but laboratory testing is needed to determine whether low SAM, elevated SAH or another impediment is actually present

Understanding LL-37 is important not as a therapeutic peptide for allergies, but as a key player in the biology of how allergic inflammation develops and resolves