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Martin DJ, Badwan K, Parker M, Mulhall JP

Betaine is used clinically to lower plasma Hcy levels in homocystinuria (Truitt et al., 2021)

Oxaliplatin affects the expression level and/or function of ion channels and induces excessive neuronal excitation, oxidative stress, and neurodegeneration through multiple mechanisms (Figure 1)

Furthermore, the fact that liver, kidney, and skeletal muscle present with similar levels of CACT and CPT2 reinforces our idea that the carnitine shuttle is not likely involved in the oxidation of FFAs since skeletal muscle does not respire when energized with FFAs of any acyl-chain length while liver and kidney do