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Bullous rash reactions including Stevens-Johnson syndrome and Lyells syndrome (toxic epidermal necrolysis), exfoliative dermatitis, erythema multiforme, and anaphylactoid reactions including anaphylactic shock, angioedema, and tongue or laryngeal edema have been reported through the postmarketing surveillance program

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S.2006Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme

Redness, barrier disruption, uneven texture, and loss of firmness drive trial