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[38] [36] A small fraction of L-leucine metabolism less than 5% in all tissues except the testes, where it accounts for about 33% is initially catalyzed by leucine aminomutase, producing -leucine, which is subsequently metabolized into -ketoisocaproate (-KIC), -ketoisocaproyl-CoA, and then acetyl-CoA by a series of uncharacterized enzymes

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Encapsulating the drug in functionalized nanocarriers (such as liposomes or recombinant apolipoprotein B lipoproteins, rABLs) enables extensive tumor penetration and controlled release, thereby significantly reducing non-targeted organ toxicity, which has been confirmed in gastric cancer models [136]