MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 1038/nature13527

1038/nature13527

Datasheet         MSDS       COA

5-ROX azide is an excellent alkyne-reactive fluorescent reagent for labeling alkyne-containing biological molecules through the well known click chemitry

Methylcyclopropene-CA CAS Number Related CAS Molecular Formula C16H28ClNO4 Molecular Weight 333

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 1038/nature13527SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,