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GRK5 is involved in cardiovascular diseases, including cardiac fibrosis, heart failure, and hypertension [12, 119,120,121,122,123,124]

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The most extensively documented mechanism involves upregulation of vascular endothelial growth factor, known as VEGF, and the broader angiogenic program

[30] emphasized the importance of innovative tools for early diagnosis of bipolar disorder (BD), the integration of biomarker research into clinical practice, and the development of novel therapeutic strategies for depressive disorders