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When AGEs bind to receptors known as RAGEs, they activate inflammatory signaling pathways like NF-B and mitogen-activated protein kinase (MAPK) and encourage the expression of fibrotic markers like TGF-1 and fibronectin (FN) in GMCs

Evaluation of oxidative stress parameters The tissue homogenate was assessed using the techniques outlined by Tsikas (2017 ) for the kidney contents of MDA determination