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If you experience persistent numbness, tingling, or weakness, consult a healthcare provider

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[] Under pathological conditions such as cardiac hypertrophy and HF, the downregulation of PGC-1 and PPAR leads to a reduction in the expression of FAO genes and a decrease in mitochondrial function, further exacerbating cardiac insufficiency

The phenotypic outcome is a shift toward higher energy expenditure and improved adipose/lipid profiles without the catabolic loss of lean tissue commonly seen with severe caloric restriction