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Collectively, these potential clinical implications support further investigation and prioritization of this strategy in future translational and clinical trials

We found that the DEGs enriched in phenylalanine and flavonoid biosynthesis pathways were unique under MD and SD treatments

It has been demonstrated that ebselen possesses otoprotective activity and alleviated NIHL in rat via preventing the loss of outer HCs and reduces the acute swelling of the stria vascularis (Kil et al., 2007), it can also attenuate cisplatin-induced ROS generation through Nrf2 activation in auditory cells (Kim et al., 2009)

To mechanistically determine whether 15LO1 pathway activation alters the intracellular redox balance, particularly under T2 conditions, these ex vivo findings were modeled in vitro in primary HAECs