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Accordingly, PDE5-Is have gained growing attention as potential therapeutic agents for the treatment of several CNS-related diseases, such as Alzheimers disease (AD), cognitive deficits, strokes, multiple sclerosis (MS), depression, noise-induced hearing loss (NIHL) and neuropathic pain that will all be discussed in this section (Figure 4)

[DOI] [Google Scholar] 209.Pulito C., Mori F., Sacconi A., Casadei L., Ferraiuolo M., Valerio M.C., Santoro R., Goeman F., Maidecchi A., Mattoli L., et al

Many experimental studies have shown that female mice are less susceptible to APAP hepatotoxicity than males and that the sex differences are substantial [17,18,35]