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NOX4 was found to be upregulated in colon adenocarcinoma tumor samples, which was associated with elevated levels of myofibroblastic-CAFs and a possible mechanism for immunotherapeutic resistance (95)

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6.1 Dietary supplementation of bilirubin-like structure Since bilirubin-like structures in plants share similar structure and function with bilirubin, complementing natural bilirubin-like structures through dietary supplementation is an effective way to elevate bilirubin levels, and one of the inexpensive and most studied bilirubin-like structures is Phycocyanobilin (PCB).PCB is a natural blue-coloring chromone with a linear tetrapyrrole structure in cyanobacteria and red algae and binds to phycocyanin (PC)