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The predicted thioredoxin fold of ROXY9 positions the putative redox active cysteines of the C 21 CLC 24 motif in a way that an intramolecular disulfide can be formed between Cys21 and Cys24, similar to the disulfide identified in CPYC-type GRXs 32,33 (Fig

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Over time, these events result in a biochemical changes including oxidative stress, altered ionic (e.g

In fact, under normal circumstances, increased ROS levels stimulate cell death, but cancer cells overcome that by activating numerous oncogenes, which then induce nuclear factor erythroid 2-related factor 2 (NRF2) expression