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The OPTION-DM trial was a multicenter, randomized, crossover study comparing three monotherapy sequences (amitriptyline, duloxetine, pregabalin) against two dual-therapy sequences in patients who had failed one monotherapy [65]

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Wen Y, Liu R, Lin N, Luo H, Tang J, Huang Q, Sun H, Tang L

Because a beneficial effect of the second generation ferrostatin 11-92 (Skouta et al., 2014) in a model of acute injury of freshly isolated renal tubules was previously reported, the morphology of such tubules in the presence of erastin, a well-described inducer of ferroptosis, a necrotic type cell death that largely depends on lipid peroxidation (Dixon et al., 2012, Yagoda et al., 2014), over time (FIG