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In strict agreement with a predominantly lysosomal function for the yeast vacuole, most of the proteins identified are either canonical vacuolar proteases or proteins involved in intermediary metabolism, protein synthesis, folding or targeting, or the alleviation of oxidative stress that have entered this compartment for salvage purposes

"Randomized trial to evaluate the clinical benefits of serum alpha-glutathione S -transferase concentration monitoring after liver transplantation"

This maladaptive process is frequently accompanied by adipocyte hypertrophy, where newly formed adipocytes accumulate excessive lipids, leading to obesity and metabolic impairment [17, 18]

10.1016/j.bbabio.2010.04.018 116 PangrazziL.BalascoL.BozziY