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Figures were generated with GraphPad Prism 8

Ni NPs can significantly reduce the body weight, serum testosterone levels, and daily sperm production in Sprague Dawley rats, while the testicular index, nickel accumulation, and histological changes in testicular tissue increase with the dose of Ni NPs [74]

Ritonavir is nowadays used primarily to increase the bioavailability of other HIV drugs as it inhibits their major metabolising enzyme, P450 3A4 monooxygenase [48, 49]