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Additionally, hydroxocobalamin tends to be better tolerated by people who are sensitive to the methyl form of B12, including those with genetic variations such as MTHFR, making it a more universally suitable option

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Arthritis Rheum 60:592603 Kondo M, Suzuki T, Kawano Y, Kojima S, Miyashiro M, Matsumoto A, Kania G, Blyszczuk P, Ross RL, Mulipa P, Del Galdo F, Zhang Y, Distler JHW (2022) Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis