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635 The depressed mice induced by intermittent alcohol consumption showed significant iron deposition, increased TFRC expression, and decreased GPX4 expression in the hippocampus and prefrontal cortex

PANORAMA and a small study from Japan that examined the efficacy and tolerability of combination therapy with inhaled NAC and pirfenidone versus pirfenidone alone had findings that suggested more rapid disease progression in the group that received combination therapy [24]

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Signal Transduct Target Therapy 2:19 [DOI] [PMC free article] [PubMed] [Google Scholar] Liu Y, Bao Z, Xu X, Chao H, Lin C, Li Z, Liu Y, Wang X, You Y, Liu N (2017b) Extracellular signal-regulated kinase/nuclear factor-erythroid2-like2/heme oxygenase-1 pathway-mediated mitophagy alleviates traumatic brain injury-induced intestinal mucosa damage and epithelial barrier dysfunction