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Zhao Y, Xu X, Liu S, Wang X, Musha J, Li T, et al

Experimental studies indicate that calycosin may modulate the Toll-like receptor (TLR) 4/NF-B signaling pathway, suppress the expression of TSLP and IL-33, and increase tight junction proteins such as ZO-1 and occludin in both human immortalized keratinocyte cell line (HaCaT) and mouse AD models (Tao et al., 2017)

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But we also want to ensure that theyre studied properly so that we know exactly what works at which dose for how long, and what the long-term safety is. For that reason, its illegal to sell these drugs for human use in Canada