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We demonstrate that riboflavin is specifically necessary for pyrimidine biosynthesis in AML, and perturbation of riboflavin metabolism induces a DNA damage response due to nucleotide imbalance that can be rescued by either attenuating de novo purine metabolism or supplementing liquid culture with pyrimidine nucleosides

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Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin

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