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For instance, downregulation of Dj1 in microglial cells has been found to induce their secretion of pro-inflammatory cytokines such as Il-1 and Il-6 and to elevate intracellular ROS 12

These findings support the involvement of the Nrf2/SLC7A11/GPx4 axis in mediating the observed protection and highlight trimetazidine, alone or with probiotics, as promising candidates for mitigating chemotherapy-induced mucosal injury

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