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Human CBS adopts a unique multi-domain structure: an N-terminal haem binding domain (residues 3874), a central PLP-dependent catalytic domain (CD, residues 75382), and a C-terminal regulatory domain (RD, residues 411551) 5,11,12 (Fig

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12,205,206,207 In line with that NAD + -capped RNA levels respond to the cellular total NAD + concentrations, the capping efficiencies of NAD + capping and NADH capping are also regulated by intracellular NAD + /NADH ratio