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Pulmonary fibrosis can be associated to connective tissue diseases or may be ascribed to radiation exposure, environmental agents such as asbestos and silica, or pharmacological agents such as bleomycin

125,126 Dysfunctional iron metabolism in COVID-19 finally leads to ferroptosis, releasing intracellular ferritin and causing ferritinemia

Since oxidation and inflammation are interconnected processes with many feedback loops 50 , excessive production of ROS and RNS by leukocytes can also trigger inflammatory responses in these immune cells