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It is normally involved in the metabolism of every cell of the body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production

As such, these two interfacial hydrogen bonds (Table 5), along with the three interfacial salt bridges (Figures 3 and 4) between Arg123, Arg127 and Glu40, led to the establishment of a delicate structural electrostatic balance, while maintaining the structural stabilization of the complex of GLP-R and semaglutide analogues, where such a delicate structural balance in hindsight entails a paradigm shift from the manual design approach in 2011 [27] to an automated systemic approach as described in this manuscript, as it does not appear so straightforwad for a manual design approach to uncover a such a delecate structural balance at a ligand-receptor binding interface [24]

PMID 36682686

G.HerzfeldJ