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These models allow researchers to zero in on and study the target TSH receptor, thyroid follicular cells, and the feedback mechanisms along the HPT axis to gain insight into how dysregulated thyroid hormone signaling contributes to metabolic disturbances associated with hyperthyroidism Kohn et al

The decreased expression of STING suppresses interferon responses, leading to a reduction in CD8 + T and NK cells in the TME, thereby enhancing the effectiveness of anti-PD-1/PD-L1 immunotherapy [123]

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