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Additional research considerations include characterizing whether the enhanced membrane permeability of the acetylated form alters tissue distribution in in vivo models, whether the modified charge distribution affects receptor or chromatin binding dynamics, and whether the extended half-life requires adjusted concentration protocols in cell culture systems

In vitro results demonstrated a significant enhancement of tumor cellular uptake, excellent mitochondria damage ability and improved antitumor efficiency of the multifunctional enveloped MSN

3h,i), differentiating HTC from previous covalent approaches and supporting the conclusion that dHTC1 operates as a molecular glue

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