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Glutathione depletion has been observed among individuals with schizophrenia and may contribute to the pathogenic changes in the brain that occur in neurodegenerative diseases.40 Huang noted that a rare mutation of the MTRR gene, which controls production of the MTR enzyme, was found in an adult patient with schizophrenia who had an elevated plasma homocysteine level.41 Supplementation with B vitamins improved negative symptoms in patients with schizophrenia who were diagnosed with genetic defects affecting folate metabolism.39 A randomized clinical trial in which 42 patients experiencing schizophrenia were treated daily for three months with 2 mg folate, 25 mg vitamin B6, and 400 ug vitamin B12 reported significant reductions in plasma homocysteine levels and improved clinical symptoms compared with control participants.35 Liu and colleagues looked at the effects of vitamin supplementation in a metaanalysis of 16 studies of healthy adults with normal or mildly elevated plasma homocysteine levels (N=1,369)

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JIMD Rep (2022): 111

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