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Importantly, curcumin demonstrates a multifaceted epigenetic influence that encompasses the inhibition of DNA methyltransferases leading to DNA demethylation and reactivation of silenced tumor-suppressor genes, modulation of histone acetylation and methylation balance to restore normal chromatin accessibility, regulation of non-coding RNAs such as microRNAs, lncRNAs, and circRNAs that control gene expression, and alteration of RNA methylation (m 6 A modification) through modulation of METTL3, FTO, and YTHDF proteins, which influence mRNA stability and translation efficiency

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*Correspondence: Lorella Maria Teresa Canzoniero, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

While they may contain certain compounds, they also contain substances that can be difficult to digest or even toxic in large quantities