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* Correspondence: Li-You Chen, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Tesamorelin (elimination half-life approximately 8 minutes after subcutaneous administration, once-daily dosing, FDA-approved, Phase 3 visceral fat data) and CJC-1295 (DAC-modified, approximately 8-day half-life, once-weekly dosing, no approved indication) represent fundamentally different engineering approaches to GHRH agonism [5]

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