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Nevertheless a dose-related decrease in the combined expression of five miR-34a target genes was observed, leading the authors to conclude that the study demonstrated proof-of-principle for miRNA-based therapy [107]

Important physiological processes, such as defensive mechanisms like the respiratory burst, thyroid hormone production, and the metabolism of important signaling chemicals like prostaglandins and arachidonic acid, are directly supported by this regulatory network

There is a need for more extensive preclinical studies and clinical trials to establish optimal doses, efficacy, and safety of these natural compounds

The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis