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In methionine-choline deficient (MCD) diet-induced NAFLD mice, L-carnitine upregulated hepatic PPAR protein expression while inhibiting NF-B p65 activation, thereby attenuating liver inflammation and fibrosis (77)

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Also, Escherichia coli , Citrobacter , Klebsiella pneaumoniae , and Shigella , Achromobacter from the strain of Betaproteobacteria , Sporosarcina from Firmicutes , and Actinobacteria have enzymes that can lead to the conversion of all food compounds including choline, betaine, lecithin, gamma-butyrobetaine, ergothioneine and L-carnitine into TMA

10.1139/O07-018 [DOI] [PubMed] [Google Scholar] Malamy J., Carr J