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Other Considerations: Monitoring: Regular monitoring of vitamin B12 levels, complete blood counts, and neurological function is advisable, especially in long-term use
While animal and early human studies indicate possible roles in adipose regulation, the compound remains under investigation across several scientific fields
One 12-week randomized clinical trial found that subjects receiving 1mg daily lost an average of 2.6kg compared to 0.8kg in the placebo group
A general finding is that obese patients fulfilling criteria for MetS together with low IGF-1 plasma levels tend to develop a worse cardiovascular disease outcome than those with mid-normal to high-normal IGF-1 levels [213]
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