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Baicalin exerts neuroprotective effects via inhibiting activation of GSK3/NF-B/NLRP3 signal pathway in a rat model of depression

Redox-active vitamin C suppresses human osteosarcoma growth by triggering intracellular ROS-iron-calcium signaling crosstalk and mitochondrial dysfunction

Given the central role of the JAK/STAT pathway in the pathogenesis of AA, it represents a therapeutic target that has opened new avenues for understanding and managing the disease.5 Currently, two therapies have been approved for severe AA: baricitinib, an oral JAK1/2 inhibitor, approved for the treatment of adults (18 years),9 and ritlecitinib, an oral dual selective inhibitor of the JAK3/TEC kinase family, approved for patients aged 12 years

Therefore, its directionality may vary depending on the stimulatory context and tissue microenvironment