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Haematological responses typically occur within 1-2 weeks, but neurological recovery may take months and can be incomplete if the deficiency has been prolonged

(2005) Recombinant, nonglycosylated human insulin-like growth factor-binding protein-3 (IGFBP-3) is degraded preferentially after administration to type II diabetics, resulting in increased endogenous glycosylated IGFBP-3