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In-silico docking and molecular dynamics corroborate the complex preferentially binding within the minor groove across a six-base pair binding site with binding predominantly stabilised by electrostatic forces augmented by van der Waals interactions that are otherwise lacking when the complex resides in the major groove

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It is reported that low concentrations of H 2 O 2 can activate melanin synthesis and increase melanosome transfer into keratinocytes [9, 10]

This means even if theoretical highest dose is administered and delivered in body, one cant deliver GHK-Cu in sufficient quantities over period of 24 hrs