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The 6-min walk test No significant changes were recorded for any supplement group (Table 2)

Okuno M, Goumard C, Mizuno T, Kopetz S , Omichi K, Tzeng CD, Chun YS, Lee JE, Vauthey JN, Conrad C

Melatonins decline in aging has widespread implications weakening circadian coordination, diminishing sleep quality, lowering antioxidant defense, increasing inflammation, and reducing neuroprotection, all of which may contribute to accelerated aging and age-related diseases

49 Increasing evidence has shown that Th17 cells producing inflammatory cytokine IL-17 further recruit monocytes/macrophages and neutrophils to the site of infection and stimulate other cytokine cascades, such as IL-1 and IL-6 among others