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In addition, the expression of MCC, PCC, PC, and AC decreased, indicating metabolic dysfunction (249)

The formulation challenge is that CoQ10 is fat-soluble and poorly suited to simple dry capsules, while many L-carnitine forms are water-soluble, high-dose, and moisture-sensitive

Building upon the contribution of microbial metabolites to the improvement of immunotherapeutic outcomes, another study demonstrated that Limosilactobacillus reuteri (LR) produces indole-3-aldehyde (I3A), a tryptophan-derived metabolite that activates the AHR, thereby promoting IFN- and enhancing anti-tumor immune responses