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These findings are consistent with previous literature reports, suggesting that Staphylococcus is the main causative genus responsible for the microecological dysbiosis of the skin in PSO patients ( Figure 5 Furthermore, KEGG enrichment analysis based on the metagenomeSeq results revealed the degradation of metabolic pathways such as Steroid hormone biosynthesis, Fluorobenzoate degradation, and N-Glycan biosynthesis in PSO model mice