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Enterotypes in the landscape of gut microbial community composition

The uptake of oxidized-low density lipoprotein (oxLDL) was also decreased by butyrate treated cells ( In high-fat diet-fed ApoE / mice, butyrate administration (200 and 400 mg/kg) influenced the microbial composition of the gut and improved diversity in favor of increasing Firmicutes specially Bacteroidetes ( in vivo , ex vivo and in vitro investigations illustrated that butyrate induces ATP-binding cassette subfamily A member 1 (ABCA1) activity in both hepatocytes and macrophages via transcription factor specific protein 1 (Sp1), which causes reduced total cholesterol (TC) and also cholesterol deposition in plaque ( Inflammation and oxidative stress are well-known in the pathogenesis of atherosclerosis ( Taken together, these findings indicate that athero-protective effects of butyrate are accompanied by regulating the expression of genes related to lipid and glucose metabolism, improving gut microbiota diversity, suppressing a wide range of inflammatory and oxidative processes, rescuing protective KLF2, and enhancing vascular health

However, the use of these drugs has been met with limited success in solid tumors thus far

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