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CGRP is another neuropeptide that increases neurons sensitivity to painful stimuli and contributes to the development of neurogenic inflammation

Diagnosed thyroid disorders are associated with depression and anxiety

In addition, long-lived radionuclides are required to match the biological half-life of mAb-based tracers due to their interaction with the neonatal Fc receptor (FcRn) in endothelial cells, which protects serum IgG from degradation [106]

Finally, the relative contributions of direct neuronal regulation versus indirect effects via immune cells (e.g., macrophages) to the observed anti-inflammatory effects remain undetermined