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Another point of interest regarding B12 supplementation is the commonly held belief that intramuscularinjections of B12 are more effective than oral supplementation

Kiefer and Copley, 2002)

The BUN/Creatinine ratio is a blood test that compares the levels of blood urea nitrogen (BUN) to creatinine in the blood

Tian et al., 2022) have confirmed that Bifidobacteria can be used to treat depressive symptoms, but the underlying mechanisms have not been completely elucidated, which may be related to reducing the abundance of pathogenic bacteria, exerting the anti-inflammatory effects, improving the permeability of intestinal barrier, regulating the tryptophan levels, affecting 5-hydroxytryptamine (5-HT) synthesis, and regulating hypothalamus-pituitaryadrenal (HPA) axis (Figure 1)