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MDM2-MDM4 RING inhibitors (MMRi) such as MMRi62 and MMRi71, which were initially designed to inhibit the MDM2MDM4 interaction to stabilize p53 [137], have recently been demonstrated to trigger the death of cancer cells

During hypoxia -ketoglutarate may also be converted to citrate, which is used for fatty acid synthesis, amino acids synthesis, or production of the reducing agent NADPH

Pathway enrichment analysis showed that our hamster model shared a relevant number of important pathways involved in NASH pathophysiology (Figure1B)

Peptides were required to be quantified in a minimum of 2 experiments to be included in the final table