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In addition, the results represented an improvement in EDSS, muscle strength, and bladder function, respectively, following intrathecal MSC-NP administration

We bring forward the hypothesis that inflammation via prolonged activation of key kinases (p38 and GSK-3) and activation of histone deacetylases gives rise to dysregulation of the NRF2 system in the brain, which contributes to oxidative stress and injury

The trial was reviewed and approved by the Medicines and Healthcare products Regulatory Agency (MHRA)