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While vitamin B12 is generally considered safe, even at high doses, the concept of "too much vitamin B12" is worth exploring

Hong, D

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Spine immobility from fibrosis and ossification is a major complication Vision damaging eye inflammation can also occur Fracture of fused spine can lead to damage to the spinal cord Stiffness of the spine and chest wall can make breathing difficult Inflammation of aorta or major artery coming from heart Inflammation of the kidney is rare Early heart disease due to chronic inflammation leading to heart attacks can occur in ankylosing spondylitis Early and effective therapy can prevent most of these complications