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Additionally, NKX2-2, a recognized embryonic stem cell transcription factor, was demonstrated to transcriptionally activate KIAA1429 and other m6A RNA methylation writers, hence amplifying oncogenic signaling

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Nguyen TT, Dung Nguyen TT, Vo TK, Tran N-M-A, Nguyen MK, Van Vo T, Van Vo G

Key distinctions from growth hormone include [5] : Peptide lacks growth hormone receptor binding domains (specifically binding site 2) Binding site 2 is required for receptor dimerization and activation Competitive binding assays showed AOD9604 cannot compete with hGH for receptor binding Does not function as a growth hormone receptor antagonist Glucose Metabolism Preservation Unlike full hGH, which can induce insulin resistance and hyperglycemia, AOD9604 demonstrates no adverse effects on carbohydrate metabolism