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Pediatr Nephrol 14(7):701706 Fine RN, Stablein D (2005) Long-term use of recombinant growth hormone in pediatric allograft recipients: a report of the NAPRTCS transplant registry

Modifications in lipid metabolism could have multiple consequences including changes in gene expression and cellular functions, protein distribution and function and membrane compositions, which could lead to development of inflammation and various diseases 82

doi: 10.1158/0008-5472.Can-09-2587 98 AmaralMMDavioCCeballosASalamoneGCanonesCGeffnerJet al

The amount of cytochrome c oxidase negative muscle fibers in treated mice decreased by 30%, the citrate synthase activity in muscle as a marker of mitochondrial biogenesis was doubled, liver lipid levels were restored and muscle mitochondrial ultrastructure was normalized (no ragged red fiber-like muscle fibers or mitochondria with distorted structure and cristae on electron microscopy)