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For example, recent studies have demonstrated that frataxin deficiency in a conditional knockout mouse model triggers SIRT3 inhibition, resulting in marked hyperacetylation of numerous cardiac mitochondrial proteins (Wagner et al., 2012) that may lead to an increased sensitivity to oxidative stress

In the context of neurological symptoms, even the combination of holo TC, MMA and homocysteine tests can be misleading

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Enhanced glucose control for preventing and treating diabetic neuropathy