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Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)

Importantly, preexisting T cells have been shown to not only be cross-reactive to SARS-CoV-2 sequence peptides in vitro but also respond in vivo and have been associated with early control of viral infection, limited disease and stronger responses to vaccination [62, 68, 92, 93]

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