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The mean change in body weight from baseline to week 104 was 15.2% in the semaglutide group ( n = 152) versus 2.6% with placebo ( n = 152), for an estimated treatment difference of 12.6 %-points (95% confidence interval, 15.3 to 9.8

Common symptoms of a B12 deficiency include fatigue, heart palpitations, headaches, depression, and more

The upstream mechanism by which this happens has been a subject of mechanistic investigation, with hypotheses ranging from direct nuclear localization of the copper complex to indirect signaling via copper-dependent enzyme activity (notably superoxide dismutase 1, SOD1) and downstream transcription factor modulation

Patient characteristics are provided in Supplemental Table 1