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Furthermore, there is an important connection between the permeabilization of mitochondria outer membrane and autophagy, as p62 serves as a tag regulating PUMA degradation, leading to a reduced apoptosis (Thorburn et al., 2014)

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It is understood that the AKT pathway could be reactivated despite IGF-1R downregulation, mediated by anti-IGF-1R antibody or TKIs, leading to tumor progression ( in vitro and in BC