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But the health and bone quality of the animal is very important

In vitro, MM/MTXNPs diminished lipid accumulation in foam cells, while in vivo, they exhibited increased accumulation at plaque sites and more potent therapeutic effects in inhibiting plaque progression compared to free MTX or MTXNPs, thereby establishing HSP as a promising platform for effective and biocompatible atherosclerosis treatment [169]

It is notable that the beneficial effect of ARA 290 appears to be sustained for at least the 28-d follow-up period

Xiang, K, Wang, E, Mantyh, J, Rupprecht, G, Negrete, M, Sanati, G, Hsu, C, Randon, PM, Dohlman, AB, Kretzschmar, K, Bose, S, Giroux, N, Ding, S, Wang, L, Balcazar, JP, Huang, Q, Sundaramoorthy, P, Xi, R, McCall, S, Wang, Z, Jiang, C, Kang, Y, Kopetz, S , Crawford, G, Lipkin, SM, Wang, XF, Clevers, H, Hsu, D, Shen, X